ADVANCEMENTS IN MAGNETIC MICROSPHERES AS TARGETED DRUG DELIVERY VEHICLES: A COMPREHENSIVE REVIEW

Abstract

Currently, non-uniform external magnetic fields generated by rare-earth permanent magnets or electromagnets are used to target tumors in vivo with magnetic microspheres. Magnetic embolization therapy, which uses magnetic particles containing anticancer agents like chemotherapeutic drugs or therapeutic radioisotopes, is one application for this method. One approach to local or regional antitumor treatment is drug targeting. One possibility for drug targeting is magnetically controlled drug targeting. This technology works by binding an anticancer drug to ferrofluids, which then use magnetic fields to concentrate the drug in the area of interest (the tumor site). The creation of a drug delivery system with a magnetic target has received a lot of attention. These medication conveyance frameworks plans to convey the medication at a rate coordinated by the necessities of the body during the time of treatment, and focus on the movement element to the site of activity. In addition to discussing the mechanism of magnetic targeted delivery, drug release rate in vitro, as well as the advantages and disadvantages of magnetic targeting, this paper provides an overview of the current application of magnetic microspheres (ferrofluid) in conjunction with magnetic fields to the most recent advancements in medical application, particularly to anticancer therapy. Keywords: Cholangiocarcinoma, Ferromagnetic, Magnetic microspheres, drug targeting using magnetic fields.