NANOSUSPENSION TECHNOLOGY: A PROMISING STRATEGY FOR IMPROVING BIOAVAILABILITY OF POORLY SOLUBLE DRUGS

Abstract

Due to their low water solubility, the majority of the novel chemical entities discovered through high-throughput screening in the drug discovery process fail. When drugs that are poorly soluble in water are prepared in conventional dosage forms, many issues arise. The excessively low bioavailability of poorly soluble drugs is one of the most serious issues. Since drugs in the BCS CLASS II category are poorly soluble in both aqueous and organic media and have a log P value of 2, the issue is even more complicated. To address the issues of low bioavailability and low solubility, a variety of formulation strategies are available. Because of their limitations, these methods for improving solubility have limited application in improving solubility. The issues that arise from these conventional approaches to improving solubility and bioavailability can be solved with the help of nanotechnology. The practice of science and engineering at the 10-9 meter nanoscale is referred to as nanotechnology. The current article depicts the insights concerning nanosuspensions. The pure, poorly water-soluble drug suspended in dispersion in nanosuspensions lacks any matrix material. The pharmaceutical applications, characterization and evaluation parameters, and preparation methods with their advantages and disadvantages are all discussed in the review article. Not only does a nanosuspension resolve the issues of low solubility and bioavailability, but it also alters the drug's pharmacokinetics, increasing its safety and effectiveness.